| American Int'l | 5 | Air Force | 3 | F | Box | AI: Adam Pleskach 1g, 1a AI: Tomas Benovic GWG 3rd 4:38 AI: Nielsson Arcibal 1eng, 1a |
| Alaska-Fairbanks | 1 | Michigan State | 1 | F-OT | Box | AF: Scott Greenham 30 saves MS: Drew Palmisano 27 saves MS: Trevor Nill 1g |
| Boston U | 4 | Massachusetts | 3 | F | Box | BU: Charlie Coyle 1g, 1a MA: Darren Rowe 2g MA: Daniel Hobbs 3a |
| Bowling Green | 5 | Alabama-Huntsville | 4 | F-OT | Box | BG: Ryan Peltoma GWG, 1a AH: Jamie Easton 2g BG: Mike Fink 1g, 1a |
| Canisius | 4 | Sacred Heart | 1 | F | Box | CAN: Steven Shafer 1g, 2a CAN: Dan Morrison 37 saves | Win CAN: Torrey Lindsay GWG, 1a |
| Clarkson | 5 | Bentley | 1 | F | Box | CLA: Ben Sexton 1g, 2a CLA: Matt Zargo 1g, 2a CLA: Adam Pawlick 1g, 1a |
| Denver | 4 | Wisconsin | 2 | F | Box | DEN: Jason Zucker 2g DEN: Drew Shore 1g, 1a DEN: Sam Brittain 26 saves | Win |
| Ferris State | 2 | Ohio State | 1 | F | Box | FS: Pat Nagle 25 saves | Win FS: Kyle Bonis GWG, 1a FS: Nate Henning 1g, 1a |
| Lake Superior State | 2 | Colgate | 1 | F | Box | LSSU: Brian Mahoney 31 saves | Win LSSU: Dan Barczuk GWG 2nd 2:16 LSSU: Domenic Monardo 1g |
| Maine | 7 | North Dakota | 3 | F | Box | UM: Brian Flynn 2g UM: Robby Dee 1g, 1a UM: Tanner House 1g, 1a |
| Mass-Lowell | 5 | Providence | 4 | F-OT | Box | MAL: Riley Wetmore GWG OT :36 MAL: Joseph Pendenza 1g, 2a MAL: Chad Ruhwedel 1g, 2a |
| Miami (OH) | 4 | Northern Michigan | 0 | F | Box | MOH: Cody Reichard 21 save so win MOH: Andy Miele 1g, 3a MOH: Carter Camper 1g, 2a |
| Minnesota-Duluth | 3 | Alaska-Anchorage | 2 | F-OT | Box | UMD: JT Brown GWG OT :31 UMD: Mike Connolly 2g AA: Tommy Grant 1g |
| Minnesota State | 5 | Colorado College | 4 | F | Box | MSU: Eriah Hayes GWG, 1a MSU: Chase Grant 2g CC: Jaden Schwartz 2g |
| Nebraska-Omaha | 4 | Michigan | 2 | F | Box | UNO: John Faulkner 34 saves | Win UNO: Terry Broadhurst 1g, 1a UNO: Ryan Walters 1g |
| Northeastern | 2 | New Hampshire | 2 | F-OT | Box | NE: Mike McLauglin 2g NE: Chris Rawlings 43 saves NH: Matt DiGirolamo 37 saves |
| RPI (Rensselaer) | 4 | RIT | 1 | F | Box | RPI: Brock Higgs 2g RPI: Allen York 24 saves | Win RPI: Tyler Helfrich 1g |
| St. Cloud State | 5 | Minnesota | 2 | F | Box | SCSU: Mike Lee 40 saves | Win SCSU: Garrett Roe 1g, 2a SCSU: Tony Mosey 1g, 1a |
| Union | 6 | Niagara | 1 | F | Box | UNI: Wayne Simpson 1g, 1a UNI: Adam Presizniuk 1g, 1a UNI: Jeremy Welsh 1g, 1a |
| Western Michigan | 3 | St. Lawrence | 1 | F | Box | WM: Nick Pisellini 27 saves | Win WM: Matt Tennyson 1g WM: Derek Roehl GWG 1st 5:33 |
